Drug Response Alleles

Our genes can affect the way our bodies metabolize certain drugs and environmental toxins.  Various SNPs have been identified that affect the metabolism of various pharmaceuticals.
rs3892097 = T (The risk of developing Parkinson's disease as a result of pesticide exposure can go up as much as 3 to 8 times).  If that is not bad enough, according to SNPedia, "If two copies of this (or similar) changes are inherited, poor metabolism ('PM') of debrisoquine [PMID 2211621] is observed. Many other drugs are typically first metabolized by CYP2D6 including dextromorphan, sparteine, metoprolol, nortriptyline and many other antidepressants and codeine. Of course, sometimes the active form of a drug is the one post-CYP2D6 metabolism; an example of this is tamoxifen, where the active form (endoxifen) is formed primarily via CYP2D6 metabolism; less functioning CYP2D6 can mean less benefit from taking the drug."

rs1065852 = A (poor metabolism of Debrisoquine)
rs130060 = C "The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs."
rs12248560 = T (Ultra fast metabolizer of estrogen, tamoxifen, proton pump inhibitors, antidepressants, etc)
rs4244285 = A (Poor metabolizer of several popular drugs including Plavix)
rs16947 = A (Ultrarapid metabolizer of Debrisoquine)